Avaliação do desenvolvimento neuropsicomotor em crianças com hepatopatias crônicas / Neuropsychomotor development evaluation in children with chronic liver diseases

Objetivos: avaliar o desenvolvimento neuropsicomotor (DNPM) de crianças de 3 a 6 anos com hepatopatias crônicas, utilizando teste de triagem de Denver II e verificar a associação entre DNPM e estado nutricional, renda familiar e intervenções cirúrgicas. Métodos: estudo seccional com grupo de comparação, descritivo e exploratório. Foram avaliadas 27 crianças, 16 do GP (grupo de pacientes) e 11 sem hepatopatias do GC (grupo comparação) pelo teste de desenvolvimento de acordo com a idade. Resultados: foi encontrado que 68,8% do GP apresentaram suspeita ou risco para o DNPM. A odds (chance) de ter o Denver positivo para suspeita ou risco no GP foi de 2,2, enquanto, entre as crianças do GC, foi de 0,375, ou seja, uma odds ratio de 5,87. Do GP, 45% com suspeita ou risco para o DNPM apresentaram-se acima do peso no IMC X Idade, 72% do GP com o Denver positivo pertenciam à classe econômica C1 e C2. No GP, 94,1% realizou algum procedimento cirúrgico; destes, mais da metade apresentou suspeita ou risco para DNPM. Conclusão: crianças com hepatopatias crônicas, acima do peso, com renda familiar baixa e as que sofreram algum procedimento cirúrgico apresentam maiores chances de suspeita ou risco para alterações no seu DNPM.

Objectives: to assess the neuropsychomotor development (DNPM) of children aged 3 to 6 years with chronic liver diseases, using Denver II screening test and check out the association between DNPM and nutritional status, family income and surgical interventions. Methods: sectional study with comparison group, descriptive and exploratory. 27 children were evaluated, 16 of the GP (Group of patients) and 11 without liver diseases (comparison group GC) for development testing according to age. Results: it was found that 68.8% of GP presented suspicion or risk for the DNPM. The odds of having the Denver positive for suspicion or risk in GP was 2.2, while among children of the GC was 0.375, i.e. an odds ratio of 5.87. The GP, 45% with suspicion or risk for the DNPM were overweight on BMI X age, 72% of GP with the positive Denver belonged to economy class C1 and C2. In GP, 94.1% conducted some surgical procedure, these more than half were suspected or risk for DNPM. Conclusion: children with chronic liver diseases, overweight, with low family income and those that suffered some surgical procedure have higher chances of suspicion or risk for changes in your DNPM.

Avaliação do desenvolvimento neuropsicomotor em crianças com hepatopatias crônicas / Neuropsychomotor development evaluation in children with chronic liver diseases

Objetivos: avaliar o desenvolvimento neuropsicomotor (DNPM) de crianças de 3 a 6 anos com hepatopatias crônicas, utilizando teste de triagem Denver II e verificar a associação entre DNPM e estado nutricional, renda familiar e intervenções cirúrgicas. Métodos: estudo seccional com grupo de comparação, descritivo e exploratório. Foram avaliadas 27 crianças, 16 do GP (grupo de pacientes) e 11 sem hepatopatias (grupo comparação - GC) pelo teste de desenvolvimento de acordo com a idade. Resultados: foi encontrado que 68,8% do GP apresentaram suspeita ou risco para o DNPM. A odds de ter o Denver positivo para suspeita ou risco no GP foi de 2,2, enquanto entre as crianças do GC foi de 0,375, ou seja, uma odds ratio de 5,87. Do GP, 45% com suspeita ou risco para o DNPM apresentaram-se acima do peso no IMC X idade, 72% do GP com o Denver positivo pertenciam à classe econômica C1 e C2. No GP, 94,1% realizaram algum procedimento cirúrgico; destes mais da metade apresentou suspeita ou risco para DNPM. Conclusão: crianças com hepatopatias crônicas, acima do peso, com renda familiar baixa e as que sofreram algum procedimento cirúrgico apresentam maiores chances de suspeita ou risco para alterações no seu DNPM.

Objectives: to assess the neuropsychomotor development (DNPM) of children aged 3 to 6 years with chronic liver diseases, using Denver II screening test and check out the association between DNPM and nutritional status, family income and surgical interventions. Methods: sectional Study with comparison group, descriptive and exploratory. 27 children were evaluated, 16 of the GP (Group of patients) and 11 without liver diseases (comparison group GC) for development testing according to age. Results: it was found that 68.8% of GP presented suspicion or risk for the DNPM. The odds of having the Denver positive for suspicion or risk in GP was 2.2, while among children of the GC was 0.375, i.e. an odds ratio of 5.87. The GP, 45% with suspicion or risk for the DNPM were overweight on BMI X age, 72% of GP with the positive Denver belonged to economy class C1 and C2. In GP, 94.1% conducted some surgical procedure, these more than half were suspected or risk for DNPM. Conclusion: children with chronic liver diseases, overweight, with low family income and those that suffered some surgical procedure have higher chances of suspicion or risk for changes in your DNPM.

Multidrug resistance 1 gene polymorphisms may determine Crohn's disease behavior in patients from Rio de Janeiro

OBJECTIVES: Conflicting data from studies on the potential role of multidrug resistance 1 gene polymorphisms in inflammatory bowel disease may result from the analysis of genetically and geographically distinct populations. Here, we investigated whether multidrug resistance 1 gene polymorphisms are associated with inflammatory bowel diseases in patients from Rio de Janeiro. METHODS: We analyzed 123 Crohn's disease patients and 83 ulcerative colitis patients to determine the presence of the multidrug resistance 1 gene polymorphisms C1236T, G2677T and C3435T. In particular, the genotype frequencies of Crohn's disease and ulcerative colitis patients were analyzed. Genotype-phenotype associations with major clinical characteristics were established, and estimated risks were calculated for the mutations. RESULTS: No significant difference was observed in the genotype frequencies of the multidrug resistance 1 G2677T/A and C3435T polymorphisms between Crohn's disease and ulcerative colitis patients. In contrast, the C1236T polymorphism was significantly more common in Crohn's disease than in ulcerative colitis (p = 0.047). A significant association was also found between the multidrug resistance 1 C3435T polymorphism and the stricturing form of Crohn's disease (OR: 4.13; p = 0.009), whereas no association was found with penetrating behavior (OR: 0.33; p = 0.094). In Crohn's disease, a positive association was also found between the C3435T polymorphism and corticosteroid resistance/refractoriness (OR: 4.14; p = 0.010). However, no significant association was found between multidrug resistance 1 gene polymorphisms and UC subphenotypic categories. CONCLUSION: The multidrug resistance 1 gene polymorphism C3435T is associated with the stricturing phenotype and an inappropriate response to therapy in Crohn's disease. This association with Crohn's disease may support additional pathogenic roles ...